There were higher levels of the proteolytically cleaved chemerin forms in ovarian carcinoma ascites than in samples either of the other two cohorts of participants with normal BMI (<25) or people with obesity with BMI > 40, showing that the ascitic environment is inflammatory, allowing generations of physiological-relevant levels of active chemerin. This evidence concerns the gene RARRES2 and obesity due to melanocortin 4 receptor deficiency.