RB1 and neoplasm: The genes involved in cellular growth and signaling that exhibit altered methylation status are as follows: CDK1, CDKN1B, CDKN2A, CDKN2C, retinoblastoma transcriptional corepressor 1 (RB1), CDKN2A protein (p16INK4a), retinoblastoma (Rb), the CDKN1B protein (p27kip1), GADD45γ, RASSF1A, RASSF3, apoptotic regulators, the pituitary tumor apoptosis gene (PTAG), MEG3, and FGFR2 [70].