GZMB and neoplasm: Specifically, the cytotoxic GZMB+ CD4+ cells (in blood), and GZMB+ and GZMK+ CD4+ cells (in tumor) were significantly enriched among CD4+ cells expressing a matched TCR, compared with total CD4+ cells where these cytotoxic phenotypes were not at all enriched (individual patient data Supplemental Figure 2, aggregate data Figure 2A, statistics Supplemental Dataset 6).