Furthermore, as shown in Figure 6C–E, CD82, MAPK14, NEDD4, and TXN were significantly positively correlated with M1-type macrophage infiltration, which is consistent with previous reviews indicating that M1-type macrophages are a key factor in the intense inflammatory response and tissue damage in the early stages of sepsis-induced acute lung injury [69]. The gene discussed is NEDD4; the disease is injury.