IHC and immunofluorescence analyses of renal biopsies from the proband and other patients indicated that the proband had higher renal tubular ATP6V0A4 protein expression abundance compared with patients with minimal change nephropathy, IgA nephropathy, or focal segmental glomerulosclerosis (Figure 2, G and H). This evidence concerns the gene ATP6V0A4 and focal segmental glomerulosclerosis.