In this study, 70 inflammation-related proteins that may be causally associated with Bell’s palsy were identified by MR analysis, and 7 significantly related proteins were screened by external dataset validation, including BLVRB, HMOX2, TNFRSF12A, DEFB128, ITM2A, DDX58 and VEGF-A. This evidence concerns the gene DEFB128 and Bell's palsy.