Using DepMap’s RNA interference (RNAi) data across synovial sarcoma cell lines and the genes that orchestrate precise DNA methylation patterns, we observed that DNMT1 is the only enzyme that displayed partial dependency, with a gene effect (Chronos) value approaching −1, which is comparable to the median of all pan-essential genes (Figure 1C). The gene discussed is DNMT1; the disease is synovial sarcoma.