Moreover, this is the first time that a link between IL-8 circulating levels and motor performance is reported [45], but there is growing evidence that suggests a possible role of IL-8 in Alzheimer’s disease (AD) pathogenesis, as IL-8 is usually upregulated in AD, favoring neuroinflammation [46,47,48,49]. The gene discussed is CXCL8; the disease is early-onset autosomal dominant Alzheimer disease.