In contrast to control cells, and in contrast to the mild protection observed with OCA-B deficiency in standard C57BL/6 EAE, mice adoptively transferred with T cells lacking OCA-B were almost completely protected from clinical disease regardless of their polarization state (Figure 2A and Supplemental Figure 3, F and G). The gene discussed is POU2AF1; the disease is hyperinsulinemic hypoglycemia, familial, 4.