When used to monitor periodontal treatment in patients with severe periodontitis (stage III and IV), an aMMP-8 PoC test was the most efficient and precise discriminator, with an optimal cut-off of 20 ng/mL compared to the total MMP-8, tissue inhibitor of MMPs (TIMP)-1, aMMP-8 RFU activity assay, PMN elastase, calprotectin, and interleukin-6 after 6 weeks of NSPT [19,29,30]. The gene discussed is MMP8; the disease is periodontitis.