Furthermore, Halade et al. have proven that sleep loss, when combined with excessive dietary fat consumption in post-myocardial infarction (MI) rats, triggered not only changes in the gastro-intestinal microbiome but also an increase in inflammatory prostaglandins and cytokines, such as IL1-β and IL-6, aggravating ongoing HF [89]. The gene discussed is IL1B; the disease is myocardial infarction.