TGFB1 and hypertrophic cardiomyopathy: Additionally, the six primary pathways that were significantly down-regulated included Dilated Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), Hypertrophic Cardiomyopathy (HCM), Vascular Smooth Muscle Contraction, Propanoate Metabolism, and the TGF-Beta Signaling Pathway (Figure 9C).