Through comprehensive analysis, this study elucidated the expression patterns of 12 IRFGs in the TME of thyroid cancer, including ACTB, CTSZ, PSME1, KLF2, CCL5, HMOX1, SPI1, ACSL5, CYBB, KPNA2, NCF2, and HSD17B11. Here, KLF2 is linked to thyroid cancer.