Of note, metastatic lymph nodes and inflamed lesions had a significantly higher standard uptake value (SUVmax) compared to healthy lymph nodes and healthy tissue, and patients with a higher SUVmax had a better OS, likely due to a greater amount of CD8+ T cells activated in secondary lymphoid organs (e.g., spleen, lymph nodes) and subsequently in infiltrating tumor lesions. This evidence concerns the gene CD8A and neoplasm.