While it contributes to apoptosis in response to DNA damage as part of a tumor surveillance mechanism, abundant expression of E2F1 in advanced cancer cells drives metastatic transformation by promoting epithelial-to-mesenchymal transition (EMT), neoangiogenesis, extravasation, and genomic instability, which correlates with poor prognosis [26,27,28]. The gene discussed is E2F1; the disease is neoplasm.