To date, the exact mechanisms by which an infected patient progresses to severe dengue are still unknown; however, all such patients present one common feature: an exaggerated inflammatory response, characterized by the elevated serum concentrations of pro-inflammatory cytokines such as IL-6, IL-8, TNF-α, CXCL10, CXCL11 and RANTES [106]. This evidence concerns the gene TNF and dengue disease.