Following the recognition of the spike protein, TLR2, an additional Toll-like receptor activated during this infection, dimerizes with TLR1 or TLR6, thus initiating a cascade causing a strong inflammatory response that leads to the activation of pro-inflammatory cytokines such as IL-6, IL-1β IL-6, IL-1β, TNFα, CXCL1, CXCL2, and CCL2 [95]. This evidence concerns the gene IL6 and infection.