Interestingly, increased Mapk3 expression and phosphorylation have been associated with increased dendritic arborization and the premature maturation of synapses in cortical pyramidal neurons in an animal model of 16p11.2 microduplication, a copy number variation strongly associated with SCHZ [101], possibly leading to the impaired formation of neuronal networks and associated cognitive deficits. The gene discussed is MAPK3; the disease is Cognitive impairment.