NFKB1 and acute myeloid leukemia: To understand the impact of increased SAA1 expression in the BM microenvironment of patients with AML, our in silico results revealed that SAA1 could activate inflammatory signaling pathways in other tumors and that these pathways are associated with cell invasion, metastasis, migration and drug resistance by activating the transcription factor nuclear factor kappa B (NF-κB) [46].