Persistent signaling of the nonclassical NF-κB pathway upregulates pro-growth and anti-apoptotic functions in multiple B cell cancers, including multiple myeloma, Hodgkin’s lymphoma, mantle cell lymphoma, adult T-cell leukemias/lymphomas, and diffuse large B-cell lymphoma (DLBCL) [32,50,51]. This evidence concerns the gene NFKB1 and AL amyloidosis.