A more detailed study of BAFF-secreted levels in the HCL-c and HCL-v disease microenvironment will reveal the role of microenvironmental BAFF in chemo-protection, and this will help to design new combination therapies to inhibit BAFF receptors or neutralize BAFF or both in combination with chemotherapy to sensitize drug-resistant cancer cells. Here, TNFRSF13C is linked to cancer.