CACNA1C and Behcet disease: In addition, two independent genome-wide association studies have identified loci that show significant associations with BD, neurotransmitter transporters (e.g., GRIN2A), proteins involved in signal transduction (e.g., DGKH), encompassing genes related to ion channels (e.g., CACNA1C and SCN2A), and synaptic plasticity proteins (e.g., ANK3) [64,65].