Furthermore, serum acetylcholine (ACh) reduces the production of inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-18) through the alpha 7 nicotinic acetylcholine receptor subunit (α7nAChR) hereby preventing systemic inflammatory response syndrome (SIRS) development [27,30,31]. This evidence concerns the gene IL18 and systemic inflammatory response syndrome.