Notably, pathways such as IL-17 signaling, ECM–receptor interaction, oxidative phosphorylation, and TNF signaling were differentially activated across the fibroblast subpopulations (Figure 10D,E, Supplementary Figure S8C,D), suggesting functional heterogeneity within the fibroblast compartment that may contribute to tumor progression and immune modulation. The gene discussed is IL17A; the disease is neoplasm.