NOTCH1 and hepatocellular carcinoma: In HCC, high expression of KIFC3 is associated with poor overall survival and promotes HCC progression through PI3K/AKT/mTOR signaling [25], whereas upregulated KIFC3 expression in GC correlates with advanced T stage, poor prognosis in patients, and promotes cancer progression and metastasis by activating the Notch1 pathway [26].