A decrease in circulating irisin levels was not only associated with cardio- and cerebrovascular conditions and diseases (myocardial infarction, HF, hypertension, atherosclerosis, vascular dementia, stroke), osteoporosis, T2DM, obesity, and CKD but also demonstrated its discriminatory ability for the prognosis of their natural evolution [33,34,35,36,37,38]. This evidence concerns the gene FNDC5 and obesity disorder.