To assess liver fibrogenesis tendency in MAFLD, histological examination with liver Sirius Red staining was utilized and indicated amelioration of histopathologic deposition of hepatic fibrosis and collagen after EA, whereas α-BGT or deficiency of HO-1 weakened the effective effects of EA on liver fibration (Figure 3A). Here, HMOX1 is linked to Hepatic fibrosis.