Advances in structure-based drug design may enable the development of highly selective CRL inhibitors or activators [157]: (3) reconciling the conflicting findings; for instance, as shown in Table 1, mice with a whole-body heterozygous knockout of the Cul3 gene do not exhibit an anxiety-like phenotype [62,63], while those with a heterozygous knockout of Cul3 in neural progenitor cells do exhibit an anxiety-like phenotype [64]. Here, CUL3 is linked to Anxiety.