Through LASSO regression, 15 DEEGs (AGRN, EXPH5, CLIC4, TSPAN6, TGFBR3, FN1, MMP9, KRT13, THY1, HBA1, FCGBP, PFN2, BST2, EPCAM, and PIP) were identified as critical markers for predicting HNSCC development. This evidence concerns the gene KRT13 and head and neck squamous cell carcinoma.