Comparing LOX-1 expression on the surface of polymorphonuclear neutrophils (PMN) assayed simultaneously in blood (cPMN) and tracheal aspirates (tPMN) in ARDS and control patients, Kraus et al. showed that LOX-1 expression on tPMN was largely increased, while it remained stable in cPMN, reinforcing our findings of a negative transpulmonary gradient and lung trapping of LOX-1 in ARDS patients [34]. Here, OLR1 is linked to acute respiratory distress syndrome.