Using a murine model for pancreatic cancer, Maniati et al. observed that the combination of tumor necrosis factor (TNF)-α, basal Notch signaling, and IκB kinase 2—a component of the NF-κB pathway—suppresses the nuclear receptor peroxisome proliferator-activated receptor gamma (Pparg) [44]. Here, TNF is linked to familial pancreatic carcinoma.