ERAP1 and Behcet disease: In addition to the well-established role of the HLA-B*51 allele as a dominant genetic susceptibility factor, genome-wide association studies (GWASs) and targeted deep resequencing of specific immune response-related genes have identified associations between BD and rare variants in several genes, including TLR4, NOD2, MEFV (innate immunity regulator), IL-10, ERAP1 (endoplasmic reticulum aminopeptidase 1), STAT4 (signal transducer and activator of transcription 4), IL-23Receptor, and IL-12RB2 (interleukin-12 receptor subunit beta 2) [110].