Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome, Proline-Serine-Threonine Phosphatase-Interacting Protein 1.-associated myeloid-related proteinemia inflammatory (PAMI) syndrome, pyoderma gangrenosum, acne and purulent acne hidradenitis (PASH) syndrome, and pyogenic arthritis, pyoderma gangrenosum, acne and purulent hidradenitis syndrome (PAPASH) are all autoinflammatory diseases that result in persistent inflammation and tissue damage [107]. The gene discussed is PSTPIP1; the disease is bacterial arthritis.