PRL and obesity due to melanocortin 4 receptor deficiency: Nonetheless, some authors reported no significant differences between patients with obesity (BMI ≥ 30 kg/m2) and those without obesity (BMI < 30 kg/m2) in terms of prolactin levels (22.21 ± 42.95 vs. 22.22 ± 42.95, p = 0.447), pituitary volume (403.2 ± 159.7 vs. 404.2 ± 157.6, p = 0.979), or the incidence of empty sella (5.79% vs. 0%, p = 0.212); however, reduced pituitary volume was observed in patients with obesity who were unsuccessful in lowering their body weight.