To calculate the score, assign 1 point for each of the following risk factors present: (1) age >60 years, (2) multiple organ failure, (3) neutrophil-to-lymphocyte ratio >12, (4) C-reactive protein >200 mg/L, (5) infected necrosis, (6) chronic kidney disease, and (7) advanced cardiovascular disease. The gene discussed is CRP; the disease is chronic kidney disease.