mTOR pathway activation is a potential candidate driver, supported by evidence of pTau in dysmorphic neurons of FCD type II and tuberous sclerosis (TS),7 pathologies with mTOR pathway gene activating mutations,8 and the ascribed role of mTOR in tau phosphorylation and neurofibrillary tangle formation in AD.9 The gene discussed is MTOR; the disease is isolated focal cortical dysplasia type II.