ANK2 and hyperinsulinemic hypoglycemia, familial, 4: We also support previously suggested connections of multiple PD-related genes with GCase activity, such as GALC and SNCA, as well as identifying a novel potential association with ANK2. These findings could be significant for improving our understanding of how GCase deficiency is related to overall lysosomal dysfunction and how GCase functions in relation to other lysosomal enzymes.