Nutlin-3, an inhibitor of p53 degradation, effectively suppresses p53 wild-type cancer cells by interfering with the degradation of p53.(Yan et al. 2018) Cell viability assay revealed that Nutlin-3 had no effect on MTC cells (Fig. S1D), which demonstrated that p53 loss of function occurred in MTC. Here, TP53 is linked to medullary thyroid gland carcinoma.