The Surviving Sepsis Campaign 2021 guidelines suggest starting AVP at a fixed infusion rate independent of weight (up to 0.03 IU/min) as an early adjunct when NE infusion rates reach 0.25–0.50 μg/kg/min [10, 11], a threshold for AVP initiation that still needs to be validated [12, 13]. The gene discussed is AVP; the disease is Sepsis.