Obesity and hyperlactatemia was negatively associated with AVP-response (adjusted Odds Ratio [aOR] 0.30, 95%CI 0.14–0.65 and aOR 0.86, 95%CI 0.75–0.99, respectively), while a NE infusion rate ≥ 0.30 μg/kg/min showed positive odds of AVP response (aOR 2.33, 95%CI 1.06–5.14). The gene discussed is AVP; the disease is obesity disorder.