AVP and obesity due to melanocortin 4 receptor deficiency: In the sensitivity analysis, a NE infusion rate ≥ 0.30 μg/kg/min alongside higher age were associated with a reduction in NE requirement 2 h after AVP initiation (aOR 5.12, 95%CI 2.10–12.53 and aOR 1.03, 95% CI 1.01–1.06, respectively), while obesity and hyperlactatemia were no longer significantly associated (aOR 0.57, 95% CI 0.29–1.14 and aOR 0.89, 95%CI 0.78–1.01, respectively; Supplemental Table 3).