AVP and obesity due to melanocortin 4 receptor deficiency: In multivariable logistic regression analysis, obesity and hyperlactatemia were negatively associated with AVP response (adjusted Odds Ratio [aOR] 0.30, 95%CI 0.14–0.65 and aOR 0.86, 95%CI 0.75–0.99, respectively), while a NE infusion rate ≥ 0.30 μg/kg/min was associated with AVP response (aOR 2.33, 95%CI 1.06–5.14; Supplemental Table 2).