To provide a spatial distribution map of AA and PGE2 in MS lesions, FF human brain tissues from NNCs (N = 3) and MS lesions (N = 7) (Fig. 1a) were used to stratify MS brain tissue, using PLP and HLA-DR immunoreactivity to reveal the level of myelination and neuroinflammation, respectively. This evidence concerns the gene PLP1 and myeloid sarcoma.