SIRT4 and cancer: For example, the increase of acetyl coenzyme A (acetyl‐CoA), a central metabolic intermediate of multiple pathways including branched‐chain amino acid (BCAA) catabolism, has been linked to the tumorigenesis and stem cell‐like properties of a variety of cancers,[50] and the level of acetyl‐CoA was indeed elevated significantly in both PANC‐1 and MIA PaCa‐2 cells after forced expression of SIRT4 (our unpublished data).