Forced expression of α2δ1 or SIRT4 in the pancreatic cancer cell lines led to significant downregulation of Ace‐K358 levels with little effects on the total ENO1 levels (Figure 5D,E), whereas the deacetylase‐dead mutant SIRT4H161Y had no significant effect on the levels of Ace‐K358 compared with the vector alone control cells (Figure 5E). This evidence concerns the gene ACE and familial pancreatic carcinoma.