Key intestinal tight junction (TJ) proteins, such as ZO‐1, claudin‐1, and occludin, play an essential role in sustaining the integrity of the intestinal barrier.[26] Consistent with these findings, the IF staining assay revealed that γGC‐MPs significantly increased the expressions of ZO‐1, claudin‐1, and occludin in colitis tissues compared to free γGC treatment. This evidence concerns the gene OCLN and colitis.