Therefore, various treatment strategies against glycation-induced skin aging can be envisioned, such as strategy 1 to prevent the production of AGEs, strategy 2 to remove the preformed AGEs, strategy 3 to control RAGE-mediated cell signaling pathways leading to the upregulation of inflammatory gene expression and downregulation of collagen gene expression, strategy 4 to assist or enhance cellular antioxidant defense, and strategy 5 to regenerate cells and matrix environments. The gene discussed is AGER; the disease is skin aging.