The relationship between H2S and PPAR-α has not been reported in cardiomyocytes; however, in a human hepatoma cell line (HepG2), NaHS increased the expression of ATP-binding cassette transporter A1 (ABCA1) by promoting the nuclear translocation of PPAR-α, providing a fundamental mechanism for H2S’s anti-atherogenic activity since ABCA1 mediates reverse cholesterol transport [51]. This evidence concerns the gene PPARA and hepatocellular carcinoma.