By impairing antioxidant defenses—specifically, Nrf2 and its downstream targets, HO-1 and NAD(P)H:quinone oxidoreductase-1 (NQO-1)—and promoting apoptosis, FTY720 enhances the sensitivity of GBM cells to oxidative stress and TMZ-induced cytotoxicity [41]. The gene discussed is HMOX1; the disease is glioblastoma.