Therefore, given the effects due to damage from MI/R, to evaluate whether inflammation, vascular alterations, and the apoptosis process involved in the pathophysiology of MI/R can be prevented, in this study, the protective effect of KYP-2047, a selective inhibitor of PREP, a serine protease involved in the release of pro-angiogenic molecules, was investigated in MI/R damage. Here, PREP is linked to myocardial infarction.