As depicted in Figure 3G, the KEGG biological pathways with significant enrichment in the HDOE were as follows: insulin secretion, arachidonic acid metabolism, PPAR signaling pathway, glycerophospholipid metabolism, inflammatory mediator regulation of TRP channels, biosynthesis of unsaturated fatty acids, carbohydrate digestion and absorption, NF-kappa B signaling pathway, and inflammatory bowel disease. Here, INS is linked to inflammatory bowel disease.