PLXNA3 and myeloid sarcoma: Changes in menopause-related sex hormone levels have an additional negative impact on metabolic health.46 These changes are associated with changes in fat distribution patterns, visceral accumulation, and increased waist circumference47,48 and changes in metabolic biomarkers49 and decreased muscle mass.50 Consequently, menopause has a strong potential to contribute to the development or worsening of MS in females.51