A similar direction of changes in iNOS expression/activity was observed in patients with cardiomyopathy [173,176,177,178], valvular heart disease [173], coronary artery disease [180], and ischemic heart disease [177], and this suggests that iNOS is linked to heart failure (HF) itself (also in quantitative terms, NYHA class), rather than being connected to the underlying cause of the HF. Here, NOS2 is linked to cardiomyopathy.