Furthermore, Silva et al. have shown that alamandine, a renin-angiotensin-aldosterone system (RAAS) modulator, could decrease collagen deposition, reduce cardiac hypertrophy, and attenuate oxidative stress by altering critical signaling pathways like the transforming growth factor beta (TGF-β) and 5′-Adenosine monophosphate-activated protein kinase (AMPK), contributing to preventing cardiac remodeling induced by pressure overload [152]. This evidence concerns the gene TGFB1 and cardiac hypertrophy.