ACHE and colonic neoplasm: Antioxidant, antimicrobial, inhibitor of tyrosinase and xanthin oxidase; green fruits have purgative effects; when separated from the fruits, the seeds exhibited anticancer properties against human colon cancer, which was mainly attributed to the benzodioxine “americanin A”.Anxiolytic effects in a zebrafish (Danio rerio) model (alleviated Scopolamine-induced anxiety; enhanced cognitive performance; inhibited AChE activity; supported antioxidant defense mechanisms).