Kaempferol [52] and phlorizin [90] promoted glucose uptake in lipotoxicity-impaired human skeletal muscle cells and mitigated insulin resistance in FFA-treated IR HepG2 cells, respectively, through upregulating p-AMPK and PI3K/Akt/GLUT4 (Figure 3). The gene discussed is SLC2A4; the disease is Insulin resistance.