Kaempferol, as the main flavonoid of the extract of Coreopsis tinctoria and Reseda lutea L., alleviated body weight gain, FBG, serum glucose, and HbAc1 levels; ameliorated glucose tolerance, insulin resistance, the lipid profile, and liver injury; promoted glucose uptake in hyperglycemia mice compared with that in the control group [51,52,53]; and suppressed the activity of α-amylase and α-glycosidase [54], while heightening the hexokinase activity in HFD/STZ-induced diabetic rats [49]. The gene discussed is INS; the disease is Hyperglycemia.