A 3-month double-blind, placebo-controlled trial involving 50 T2DM subjects showed that the administration of 500 mg/day of rutin significantly decreased FBG, insulin, HbA1c, homeostatic model assessment of insulin resistance (HOMA-IR) (p < 0.001), interleukin 6 (IL-6), malondialdehyde (MDA) (p < 0.05) levels and improved lipid profiles [104]. This evidence concerns the gene INS and type 2 diabetes mellitus.