HM-chromanone was able to activate the IRS/PI3K/AKT channel to reduce blood glucose levels and alleviate insulin resistance contributed by the decreased phosphorylation of IRS-1ser307 and elevated GLUT4, p-FOXO1, and p-GSK-3β levels in PA-treated IR HepG2 cells and ob/ob mice [99,100,101]. Here, AKT1 is linked to Insulin resistance.