A deficiency in PRDX6 is associated with impaired sperm function and compromised DNA integrity in both human male infertility and rodent models [140,141], while its elevation may underlie the protective effects of curcumin and melatonin on sperm motility, viability, fertilization rates, and blastocyst development [42,54]. The gene discussed is PRDX6; the disease is male infertility.