For instance, in the central nervous system, PRDX6-aiPLA2 has been reported to aggravate neuroinflammation following ischemic stroke by modulating astrocyte-induced M1 microglia activation and promoting the secretion of neurotoxic inflammatory mediators, including IL-1β, IL-17, and IL-23 [133,168]. Here, PRDX6 is linked to ischemic stroke.