■Quinoline;■Investigational for Ewing sarcoma (phase 2), colorectal carcinoma (phase 1), head and neck malignant neoplasia (phase 2), hepatocellular carcinoma (phase 2), and ovarian cancer (phase 1);■Insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor inhibitor. The gene discussed is INSR; the disease is Ewing sarcoma.