In normal human bronchial epithelial cells (NHBE), the Sendai virus triggered a rapid and robust expression of multiple antiviral genes with a peak at 6 h post-infection (hpi) with the fold of increase ranging from ~15,000 (for ISG15) to 800,000 (for IFNB1) (Fig. 1A). The gene discussed is ISG15; the disease is infection.